3-phenyl-3-methoxypyrrolidine derivatives as modulators of...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/12 (2006.01) A61K 31/40 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2744308

The present invention relates to novel 3-phenyl-3-methoxy-pyrrolidine derivatives, useful for modulating extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more specifically for the treatment of central nervous system disorders. In other aspects the invention relates to pharmaceutical compositions comprising the 3-phenyl-3-methoxy-pyrrolidine derivatives of the invention and to the use of these compounds for therapeutic applications.

La présente invention concerne de nouveaux dérivés de 3-phényl-3-méthoxy-pyrrolidine utiles pour moduler les taux extra-cellulaires de catécholamines, de dopamine et de norépinéphrine, dans des zones corticales du cerveau de mammifères, et plus spécifiquement pour traiter des troubles du système nerveux central. Dans d'autres aspects, l'invention a pour objet des compositions pharmaceutiques comprenant les dérivés de 3-phényl-3-méthoxy-pyrrolidine de l'invention et l'utilisation de ces composés pour des applications thérapeutiques.

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