3-phenylazetidine derivatives as dopamine agonists

Details 3-phenylazetidine derivatives as dopamine agonists 3-phenylazetidine derivatives as dopamine agonists

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/395 (2006.01) A61P 15/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2611216

The present invention provides for compounds of formula (I) as defined herein. These compounds are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. The compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

La présente invention permet l~obtention de composés de formule (I) comme définis ici. Ces composés appartiennent à une classe d'agonistes de la dopamine, plus particulièrement à une classe d'agonistes sélectifs pour D3 plutôt que pour D2. Les composés servent à traiter et/ou à prévenir des dysfonctionnements sexuels, par exemple des troubles sexuels chez la femme, en particulier des troubles de la libido, des troubles hypoactifs de la libido (manque de désire sexuel), des troubles de l~orgasme (anorgasmie); et des dysfonctionnements sexuels chez l~homme, en particulier des troubles de l~érection. Parmi les dysfonctionnements sexuels de l~homme dont il est question ici, on inclut des troubles éjaculatoires tels qu'éjaculation précoce, anorgasmie (incapacité d~arriver à l'orgasme) ou troubles de la libido tels que trouble hypoactif du désir sexuel (manque de libido). Ces composés sont aussi utiles pour traiter des troubles neuropsychiatriques et des troubles neurodégénératifs.

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