C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/26 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2568301
A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3- dimethylaminopropyl, etc.; X represents trifluoromethyl, etc.; X' represents hydrogen, etc.; and Y and Y' each represents methyl, hydrogen, etc.), a physiologically acceptable salt thereof, or a prodrug of either. They have cytostatic activity against tumor cells and hence are effective as an antitumor agent.
Dérivé de 3-phényltétrahydrocinnolin-5-ol représenté par la formule générale suivante (1) (dans laquelle Z représente un groupe 2-carboxyéthyle, 3-diméthylaminopropyle, etc. ; X représente un groupe trifluorométhyle, etc. ; X~ représente un atome d~hydrogène, etc. ; et Y et Y~ représentent chacun un groupe méthyle, un atome d~hydrogène, etc.), sel physiologiquement acceptable de ce dérivé, ou promédicament constitué de l~un ou l~autre. Ces composés ont une activité cytostatique contre les cellules tumorales et sont donc efficaces en tant qu~agent antitumoral.
Kuroiwa Shunsuke
Maruyama Sakiko
Sato Yoshitaka
Suzuki Yoshikazu
Yamamoto Keiichiro
Marks & Clerk
Nippon Kayaku Kabushiki Kaisha
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