3-pyraz0lyl-benzamide-4-ethers, secondary amines and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/12 (2006.01) A61K 31/4192 (2006.01) A61K 31/42 (2006.01) A61K 31/427 (2006.01) A61K 31/454 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) C07D 231/12 (2006.01) C07D 231/16 (2006.01) C07D 403/12 (2006.01) C07D 411/12 (2006.01)

Patent

CA 2646076

The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.

La présente invention concerne certains composés de formule (Ia) et compositions pharmaceutiques les contenant qui modulent l'activité des récepteurs 5-HT2A de la sérotonine. Lesdits composés et compositions pharmaceutiques les contenant concernent des procédés utiles pour traiter l'agrégation des plaquettes, les affections coronariennes, l'infarctus du myocarde, les accidents ischémiques transitoires, les angines, les attaques, la fibrillation auriculaire, la formation de caillots sanguins, l'asthme ou ses symptômes, l'agitation ou l'un de des symptômes, les troubles du comportement, les psychoses induites par les médicaments ou les drogues, les psychoses excitatives, le syndrome de Gilles de la Tourette, les troubles de type maniaque, les psychoses d'origine organique ou non spécifiques, les troubles psychotiques, la psychose, la schizophrénie aigue, la schizophrénie chronique, la schizophrénie non spécifique et les troubles apparentés, ainsi que les troubles du sommeil, les troubles liés au diabète, la leucoencéphalopathie multifocale progressive, etc. La présente invention concerne également des procédés de traitement des troubles associés aux récepteurs de sérotonine 5-HT2A, lesdits procédés faisant appel à d'autres agents pharmaceutiques administrés séparément ou ensemble.

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