C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/315.5
C07D 231/02 (2006.01) C07D 231/04 (2006.01) C07D 231/08 (2006.01) C07D 231/12 (2006.01) C07D 231/54 (2006.01)
Patent
CA 1047503
ABSTRACT 3-Pyrazolidinones and pyrazolidines of the formula Image wherein A is CH-CH, C?C or C6H4, R is H, alkali metal, amine salt, alkyl or cycloalkyl, m is 0 or 1, n and p are each 0 to 6, Y and Z are each 0 or H2 provided that if one is 0, the other is H2, R1 through R5 are specified H, F, alkyl, fluorinated alkyl and/or alkanoyl radicals, Q is H, CH3, CF2CH3 or CF3, are disclosed. The compounds are prepared by selective alkylation procedures with hydrocarbyl or halohydrocarbyl groups containing these functions. The new products are surfactants. They also have pharmaceutical activity either like the natural prostaglandins or as antagonists to the natural prostaglandins. Some of the compounds, like the prostaglandins, lower blood pressure, cause bronchodila- tion, inhibit gastric secretion, inhibit epinephrine induced lipolysis, or stimulate smooth muscles. Others inhibit the prostaglandin induced stimulation of smooth muscle.
212521
E.i. Du Pont de Nemours And Company
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