3-(pyrid-3- or 4-ylalkyl)-indoles

Details 3-(pyrid-3- or 4-ylalkyl)-indoles 3-(pyrid-3- or 4-ylalkyl)-indoles

C - Chemistry, Metallurgy

07

D

260/280.3, 260/2

C07D 401/06 (2006.01) C07D 209/04 (2006.01)

Patent

CA 1143737

Abstract Compounds of the formula:- Image --- (I) where R1 is hydrogen, C1-C4 alkyl, C3-C7 cycloalkyl or phenyl; R2 is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, or halo; R3 is hydrogen or C1-C4 alkyl; X is -(CH2)n- where n is 1, 2 or 3, -CH2CH(CH3)- or Image ; Y is -COOH, -COO (C1-C4 alkyl), -CONH2, -CN or 5-tetrazolyl; snd Z is 3- or 4-pyridyl; and the pharmaceutically acceptable salts thereof. The compounds selectively inhibit the action of the thromboxane synthetase enzyme and may thus be useful in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, cancer and the vascular complications of diabetes.

392225

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