C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61P 35/00 (2006.01) C07D 213/00 (2006.01) C07D 265/00 (2006.01) C07D 277/00 (2006.01) C07D 333/00 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2461360
The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.
La présente invention concerne de nouveaux thiazoles portant des substituants 3-pyridyle ou 4-isoquinilinyle et des compositions pharmaceutiques de ceux-ci. Cette invention concerne aussi des techniques d'utilisation de ces composés et des compositions pharmaceutiques de cette invention utilisés comme inhibiteurs de lyases, par exemple de l'enzyme 17a-hydroxylase C17,20. Cette invention concerne enfin des techniques de traitement du cancer d'un patient qui consiste à administrer à ce patient un composé de l'invention ou une composition pharmaceutique de ces composés. Il peut s'agir d'un cancer de la prostate ou d'un cancer du sein, par exemple.
Achebe Furahi
Asgari Davoud
Bi Cheng
Bierer Donald
Burke Michael J.
Bayer Pharmaceuticals Corporation
Fetherstonhaugh & Co.
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