3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors

Details 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/407 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01) C07D 471/00 (2006.01) C07D 471/04 (2006.01) C07D 487/00 (2006.01) C07D 491/00 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 497/00 (2006.01)

Patent

CA 2400649

The invention relates to certain indolinone compounds of formula (I), their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

L'invention concerne des composés d'indolinone, leur méthode de synthèse et une bibliothèque combinatoire constituée des composés d'indolinone de l'invention. L'invention concerne également des méthodes de modulation de la fonction des protéines kinases à l'aide des composés d'indolinone de l'invention, ainsi que des méthodes de traitement de maladies consistant à moduler la fonction des protéines kinases et les voies de transduction du signal.

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