C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 403/14 (2006.01) C07F 9/09 (2006.01) C07F 9/572 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2409430
The present invention is directed to prodrugs of certain 3-(pyrrol-2-yl- methylidene)-2-indolinone derivatives that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
L'invention concerne des promédicaments de certains dérivés de 3-(pyrrol-2-yl-méthylidène)-2-indolinone qui modulent l'activité de protéines kinases (PK). L'invention concerne également des compositions pharmaceutiques qui contiennent ces composés, des méthodes de traitement de maladies liées à une activité anormale de PK, utilisant lesdites compositions, ainsi que des procédés de préparation de ces dernières.
Gao Ping
Koenig Marcel
Moon Malcolm Wilson
Morozowich Walter
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Sugen Inc.
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