3-pyrrolin-2-one-derivatives

C - Chemistry – Metallurgy – 07 – D

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260/322, 260/278

C07D 207/38 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1094082

A B S T R A C T The invention relates to compound of the formula Image wherein R1 and R2, which can be the same or different, are straight-chain or branched alkyl radicals containing up to 3 carbon atoms or, together with the nitrogen atom to which they are attached, can also form a saturated 5-, 6- or 7-membered heterocyclic ring which can also contain a further nitrogen atom or an oxygen or sulphur atom, A is a straight-chain or branched hydrocarbon chain containing 2 to 4 carbon atoms and R3 is a saturated or unsaturated, straight-chain or branched aliphatic hydrocarbon radical containing up to 6 carbon atoms or is the radical -Alk-Ar, wherein Alk is an alkylene chain containing up to 3 carbon atoms and Ar is a phenyl or hetero- aryl radical optionally substituted by halogen atoms and/or lower alkoxy radicals; and the pharmacologically compatible salts thereof. These new compounds exhibit anti-hypertensive and vasodilatory action.

284651

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