3-quinoline-2-(1h)-ylideneindolin-2-one derivatives

Details 3-quinoline-2-(1h)-ylideneindolin-2-one derivatives 3-quinoline-2-(1h)-ylideneindolin-2-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 209/34 (2006.01) C07D 211/22 (2006.01) C07D 215/12 (2006.01) C07D 215/60 (2006.01) C07D 263/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 4

Patent

CA 2448076

It is intended to provide vascular endothelial growth factor (VEGF) inhibitors useful as drugs, in particular, remedies for diseases in which angiogenesis participates (for example, solid cancer and diabetic retinopathy). Namely, novel 3-quinoline-2(1H)-ylideneindolin-2-one derivatives represented by the following general formula (I) or salts thereof have excellent effects of inhibiting VEGF and angiogenesis and an antitumor effect and, therefore, are useful as appropriate VEGF inhibitors, angiogenesis inhibitors and anticancer agents: (I).

L'invention concerne des inhibiteurs de facteur de croissance endothéliale vasculaire (VEGF) utilisés comme médicaments notamment pour des maladies dans lesquelles l'angiogénèse intervient, par exemple, dans l'apparition d'un cancer solide et d'une rétinopathie diabétique. L'invention concerne essentiellement de nouveaux dérivés de 3-quinoléine-2-(1H)-ylidèneindoline-2-one représentés par la formule (I) ou des sels de ceux-ci possédant d'excellents effets d'inhibition de VEGF et d'angiogénèse et un effet antitumoral. Ces dérivés sont utilisés comme inhibiteurs de VEGF appropriés, inhibiteurs d'angiogénèse et agents anticancéreux.

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