3-quinuclidinyl amino-substituted biaryl derivatives

Details 3-quinuclidinyl amino-substituted biaryl derivatives 3-quinuclidinyl amino-substituted biaryl derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/00 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2549976

Compounds of formula (I); wherein A is N or N+-O-; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6- membered aromatic rings with a -NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by .alpha.7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

La présente invention concerne des composés de formule (I) dans laquelle A représente N ou N?+¿-O?-¿; n vaut 0, 1 ou 2; Y représente O, S, -NH- et -N-alkyl-; Ar?1¿ représente des noyaux aromatiques à 6 éléments; Ar?2¿ représente des noyaux aromatiques à 5 ou 6 éléments avec un groupe -NR?8¿R?9¿. Ces composés sont utilisés pour traiter des pathologies ou des troubles que des ligands nAChR .alpha.7 permettent de prévenir ou d'améliorer. La présente invention concerne également des compositions pharmaceutiques comprenant des composés de formule (I), ainsi que des procédés pour utiliser ces composés et ces compositions.

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