3-quinuclidinyl heteroatom bridged biaryl derivatives

Details 3-quinuclidinyl heteroatom bridged biaryl derivatives 3-quinuclidinyl heteroatom bridged biaryl derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/00 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2549979

Compounds of formula (I) or (II) , or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N+-O-; m and n are each independently 0, 1, or 2; X1 and X3 are each independently O, S, and -N(R1)-; X2 is O, S, -N(R1)-, -N(Ar2)-, and -N(R2)C(O)- ; Ar1 is a six-membered aromatic ring; Ar2 is cyclohexyl or a mono- or bicyclic aromatic ring, and R13 is hydrogen, alkyl, or halogen, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formulas (I) and (II) and methods for using such compounds and compositions.

La présente invention concerne des composés de formule (I) ou (II) ou des sels, esters, amides ou promédicaments de ceux-ci, acceptables d'un point de vue pharmaceutique. Dans lesdites formules, A et G représentent chacun indépendamment N ou N?+¿-O?-¿; m et n représentent chacun indépendamment 0, 1 ou 2; X?1¿ et X?3¿ représentent chacun indépendamment O, S et -N(R?1¿)-; X?2¿ représente O, S, -N(R?1¿)-, -N(Ar?2¿)- et -N(R?2¿)C(O)-; Ar?1¿ représente un noyau aromatique à six éléments; Ar?2¿ représente cyclohexyle ou un noyau aromatique monocyclique ou bicyclique et R?13¿ représente hydrogène, alkyle ou halogène. Ces composés sont utilisés pour traiter des pathologies ou des troubles que des ligands nAChR permettent de prévenir ou d'améliorer. La présente invention concerne également des compositions pharmaceutiques comprenant des composés de formule (I) et (II), ainsi que des procédés pour utiliser ces composés et ces compositions.

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