3-((s)-1'-phenylethylamino) propylaminobleomycin, non-toxic...

Details 3-((s)-1'-phenylethylamino) propylaminobleomycin, non-toxic... 3-((s)-1'-phenylethylamino) propylaminobleomycin, non-toxic...

C - Chemistry, Metallurgy

07

H

260/228

C07H 19/00 (2006.01) C07K 9/00 (2006.01)

Patent

CA 1078831

ABSTRACT OF THE DISCLOSURE Novel 3-[(S)-1'-phenylethylamino]propylamino- bleomycin obtained by reacting a reactive derivative of the carboxyl group of bleomycinic acid with N-[(S)-1'- phenylethyl]-1,3-diaminopropane, a non-toxic salt of said novel bleomycin, and a method for producing the novel bleomycin. Because of much reduction in the side effect causing plumonary fibrosis, the novel bleomycin is more useful than a commercial bleomycin complex which gives rise to said undesirable side effect.

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