3-substituted-[1,2,3]-benzotriazinone compound for enhancing...

Details 3-substituted-[1,2,3]-benzotriazinone compound for enhancing... 3-substituted-[1,2,3]-benzotriazinone compound for enhancing...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/5365 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2674460

This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to a compound useful for treatment of such conditions, and methods of using this compound for such treatment.

L'invention concerne la prévention et le traitement de l'insuffisance cérébrale, en particulier l'amélioration du fonctionnement de récepteur des synapses des réseaux cérébraux responsables de comportements d'ordre supérieur. Lesdits réseaux cérébraux sont impliqués dans des capacités cognitives en rapport avec un handicap de la mémoire observés dans un certain nombre de démences et dans des déséquilibres de l'activité neuronale entre différentes régions cérébrales ou supposés dans des troubles tels que la maladie de Parkinson, la schizophrénie et les troubles affectifs. Selon un développement particulier, la présente invention concerne un composé utile dans le traitement de tels états et un procédé d'utilisation de ce composé dans un tel traitement.

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