3-substituted-[1,2,3]benzotriazinone compounds for enhancing...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 498/14 (2006.01) A61K 31/53 (2006.01) A61K 31/5365 (2006.01) A61K 31/5377 (2006.01) A61K 31/5383 (2006.01) A61P 25/00 (2006.01) C07D 413/06 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2674321

This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.

La présente invention concerne la prévention et le traitement de l'insuffisance cérébrale, y compris l'amélioration du fonctionnement des récepteurs dans les synapses dans les réseaux cérébraux responsables de comportements d'ordre plus élevé. Ces réseaux cérébraux sont impliqués dans les capacités cognitives liées à l'affaiblissement de la mémoire, comme il est observé dans une variété de démences et dans des déséquilibres de l'activité neuronale entre différentes régions du cerveau, comme il est suggéré dans des troubles tels que la maladie de Parkinson, la schizophrénie et des troubles affectifs. Dans un aspect particulier, la présente invention concerne des composés utiles dans le traitement de telles conditions, et des procédés d'utilisation de ces composés pour un tel traitement.

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