3-substituted-1,4-diazepan-2-one melanocortin-5 receptor...

Details 3-substituted-1,4-diazepan-2-one melanocortin-5 receptor... 3-substituted-1,4-diazepan-2-one melanocortin-5 receptor...

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/551 (2006.01) A61P 17/08 (2006.01) A61P 17/10 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2716256

The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which down-regulation of MC5R is beneficial. Such diseases and/or conditions include, but are not limited to, acne, seborrhea, seborrheic der-matitis, cancer, and inflammatory diseases. Formula (I).

La présente invention concerne des composés de formule (I) utiles pour la modulation de l'activité biologique du récepteur 5 de la mélanocortine (MC5R). Les composés de l'invention peuvent être utilisés pour traiter des maladies et/ou pathologies dans lesquelles la régulation négative du MC5R est avantageuse. Ces maladies et/ou pathologies comprennent, mais pas exclusivement, l'acné, la séborrhée, la dermatite séborrhéique, le cancer et les maladies inflammatoires.

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