3-substituted-2-oxindole-1-carboxamides as inhibitors of...

Details 3-substituted-2-oxindole-1-carboxamides as inhibitors of... 3-substituted-2-oxindole-1-carboxamides as inhibitors of...

A - Human Necessities

61

K

167/240

A61K 31/40 (2006.01)

Patent

CA 1324761

3-SUBSTITUTED-2-OXINDOLE-1-CARBOXAMIDES AS INHIBITORS OF INTERLEUKIN-1 BIOSYNTHESIS ABSTRACT This invention relates to the use of certain 3-substituted-2-oxindole-1-carboxamides of the formula Image and the pharmaceutically-acceptable base salts thereof wherein X is H, Cl or F; Y is H or Cl; and R is benzyl or thienyl to inhibit interleukin-1 biosynthesis in a mammal. This invention also relates to the use of such compounds for treating interleukin-1 mediated disorders and dysfunctions such as bone and connective tissue metabolism disorders and immune dysfunction in a mammal. The methods of this invention comprise administering an interleukin-1 biosynthesis inhibiting amount of the compounds and salts of this invention to such a mammal.

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