3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetra...

Details 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetra... 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetra...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/395 (2006.01) A61K 31/4188 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01) C07F 9/141 (2006.01)

Patent

CA 2709749

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.

La présente invention concerne d'une façon générale le domaine des composés thérapeutiques et, plus précisément, certains amides d'acides 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tétrazine-8-carboxyliques substitués en position 3 (appelés collectivement dans la description composés 3TM). La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, l'utilisation de tels composés et compositions, à la fois in vitro et in vivo, pour inhiber la prolifération cellulaire et dans le traitement de troubles prolifératifs tels que le cancer, etc. et des procédés de préparation de tels composés.

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