3-substituted-4-pyrimidone derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2510170

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof useful as a tau protein kinase 1 inhibitor:wherein X represents CH or nitrogen atom; R1 represents a C1#191- C12#191 alkyl group which may be substituted;R2 represents a C1#191-C8#191 alkyl group which may be substituted, a benzene ring which may be substituted, a naphthalene ring which may be substituted, an indan ring which may be substituted, a tetrahydronaphthalene ring which may be substituted, or an optionally substituted heterocyclic ring having 1 to 4 hetero atoms selected from the group consisting of oxygen atom, sulfur atom, and nitrogen atom, and having 5 to 10 ring-constituting atoms in total.

L'invention concerne un dérivé de pyrimidone représenté par la formule (I) ou un sel de celui-ci, un solvate ou un hydrate, utile en tant qu'inhibiteur de la protéine tau kinase 1. Dans ladite formule (I), X représente CH ou un atome d'azote ; R?1¿ représente un groupe alkyle C¿1?-C¿12? pouvant être substitué ; R?2¿ représente un groupe alkyle C¿1?-C¿8? pouvant être substitué, un anneau benzène pouvant être substitué, un anneau naphtalène pouvant être substitué, et un anneau indane pouvant être substitué, un anneau tétrahydronaphtalène pouvant être substitué ou un anneau hérétocyclique éventuellement substitué possédant 1 à 4 hétéroatomes choisis dans le groupe constitué d'atome d'oxygène, d'atome de soufre et d'atome d'azote et possédant au total 5 à 10 atomes formant un anneau.?¿

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