3-substituted adenines via2-thioxanthines

C - Chemistry – Metallurgy – 07 – D

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C07D 473/34 (2006.01) C07D 473/30 (2006.01)

Patent

CA 2313004

With the above and other objects in view, the present invention comprises compounds having general formula (I): wherein Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH2, CH2CH2, CH(CH3); alkenyl groups such as CHCH; alkynyl groups such as CC; and NH, N(C1- C3 alkyl), O, S, C(O)CH2 and OCH2; R1 and R2 are selected from the group consisting of hydrogen and a C1-C8 straight or branched alkyl or a C3-C8 cycloalkyl; R3 is a C1-C12 straight or branched alkyl; R4 is a C3-C10 cycloalkyl optionally substituted with OH or C3-C10 cycloalkenyl optionally substituted with OH; and R8 is a C1-C8 straight or branched alkyl or a C3-C8 cycloalkyl, optionally substituted with OH; and methods of synthesis.

La présente invention concerne des composés de la formule générale (I) dans laquelle: Z est sélectionné dans le groupe formé par des groupes alkyle comme des groupes alkylène tels que CH¿2?, CH¿2?CH¿2?, CH(CH¿3?); des groupes alcényle tels que CH=CH; des groupes alcynyle tels que C?C; et NH, N(C¿1?-C¿3? alkyle), O, S, C(O)CH¿2? et OCH¿2?; R?1¿ et R?2¿ sont sélectionnés dans le groupe formé par un hydrogène et un alkyle droit ou ramifié en C¿1?-C¿8? ou un cycloalkyle en C¿3?-C¿8?; R?3¿ est un alkyle droit ou ramifié en C¿1?-C¿12?; R?4¿ est un cycloalkyle en C¿3?-C¿10? éventuellement substitué par OH ou un cycloalcényle en C¿3?-C¿10? éventuellement substitué par OH; et R?8¿ est un alkyle en C¿1?-C¿8? droit ou ramifié ou un cycloalkyle en C¿3?-C¿8? éventuellement substitué par OH. L'invention concerne également des procédés de synthèse.

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