C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07D 209/42 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/5377 (2006.01) A61P 11/06 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2483091
This inventions discloses and claims 3-substituted amino-1H-indole-2- carboxylic acid and 3-substituted amino-benzothiophene-2-carboxylic acid derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interieukin- 4(IL-4) message, IL-4 release or IL-4 production.
Cette invention concerne et revendique l'acide amino-1H-indole-2-carboxylique 3-substitué, et des dérivés d'acide amino-benzo' b! thiophène-2-carboxylique substitué, utilisés pour traiter l'allergie, l'asthme, la rhinite, la dermatite, les lymphomes B, les tumeurs et les maladies associées à des infections à virus bactérien, à rhinovirus ou à virus respiratoire syncytial (RSV). L'on sait aujourd'hui que les composés de l'invention peuvent moduler les lymphocytes T auxiliaires (Th), Th1/Th2, et peuvent donc inhiber la transcription du message d'interleukine 4 (IL-4), la libération d'IL-4 ou la production d'IL-4.
Dharanipragada Ramalinga
Gross Alexandre
Hrib Nicholas J.
Jurcak John G.
Klein Joseph T.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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