3-substituted indoles and derivatives thereof as therapeutic...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 31/41 (2006.01) A61P 3/08 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2527779

The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

La présente invention concerne des indoles de la formule I et leurs sels pharmaceutiquement acceptables. Dans ladite formule, R?1¿ et R?2¿ correspondent aux valeurs telles que définies dans la spécification. Ces indoles sont utilisés comme agents dans le traitement de maladies et de pathologies, notamment les maladies inflammatoires, les maladies cardio-vasculaires, et les cancers. L'invention concerne en outre des compositions pharmaceutiques contenant un ou plusieurs composés de la formule I.

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