C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/34 (2006.01) A61K 31/40 (2006.01) C07D 209/38 (2006.01) C07D 209/60 (2006.01)
Patent
CA 2176183
There is provided novel substituted 3-phenyl oxindole derivatives of the formula (see formula I) wherein R is hydrogen, hydroxy or fluoro; R1, R2, R3 and R4 each are independently hydrogen, C1-4 alkyl, halogen, trifluoromethyl, phenyl, p-methylphenyl or p- trifluoromethylphenyl; or R1 and R2, R2 and R3 or R3 and R4 are joined together to form a benzo fused ring; R5 is hydrogen or C1-4 alkyl; and R6 is chlorine or trifluoromethyl; or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof, which are openers of the large-conductance calcium-activated potassium channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
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Gribkoff Valentin K.
Hewawasam Piyasena
Meanwell Nicholas A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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