3-(substituted)propenylaminothiazolylcephalosporanic acids...

Details 3-(substituted)propenylaminothiazolylcephalosporanic acids... 3-(substituted)propenylaminothiazolylcephalosporanic acids...

C - Chemistry, Metallurgy

07

D

260/101.5

C07D 501/20 (2006.01) A61K 31/545 (2006.01) C07D 277/28 (2006.01) C07D 277/40 (2006.01) C07D 277/42 (2006.01) C07D 417/12 (2006.01) C07D 501/00 (2006.01) C07D 501/04 (2006.01) C07D 501/06 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01) C07D 501/26 (2006.01) C07D 501/34 (2006.01)

Patent

CA 1279868

3-(SUBSTITUTED)PROPENYLAMINOTHIAZOL- YLCEPHALOSPORANIC ACIDS AND ESTERS THEREOF ABSTRACT This invention provides novel cephalosporanic acids and esters thereof having the general formula Image wherein R2 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclo (lower) alkyl or acyl, R3 is hydrogen, lower alkyl, lower alkoxy, lower alkanoyloxy, and R4 is hydrogen, pivaloyloxymethyl, acetoxymethyl, 1-acetoxyethyl, 5-methyl-2-oxo-1, 3-dioxolen-4-ylmethy} 1-(ethoxyrarbonyloxy)ethyl, or 4-glycyloxybenzoyloxymethyl. These compounds, especially esters, are useful as broad spectrum antibiotics in the treatment and prevention of infectious diseases of mammals, and for other purposes known in the art.

511752

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