3-substituted pyrrolidines useful as inhibitors of matrix...

Details 3-substituted pyrrolidines useful as inhibitors of matrix... 3-substituted pyrrolidines useful as inhibitors of matrix...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2356969

The present invention provides novel 3-substituted pyrrolidines of formula (1) useful as inhibitors of matrix metallo-proteinases (MMPs). Pharmaceutical compositions containing said compounds as well as methods of treating disease states responding to inhibition of matrix metallo-proteinase are also claimed herein.

L'invention porte sur de nouvelles pyrrolidines 3-substitutées de formule (1) utilisables comme inhibiteurs des métallo-protéinases matricielles (MMPs), sur des compositions pharmaceutiques les contenant et sur des procédés de traitement conformes à la description de différents états morbides par inhibition des métallo-protéinases matricielles.

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