3-substituted-tetrahydro-pyrrolo[1,2-a] pyrimidines, process...

Details 3-substituted-tetrahydro-pyrrolo[1,2-a] pyrimidines, process... 3-substituted-tetrahydro-pyrrolo[1,2-a] pyrimidines, process...

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 487/04 (2006.01)

Patent

CA 1149806

ABSTRACT OF THE DISCLOSURE The present invention relates to pyrrolo[1,2-a]pyrimidine-deriva- tives of the general formula Image (I) and Image (II) and a mixture thereof and pharmaceutically suitable acid addition salts and quaternary salts thereof, wherein R stands for hydrogen or lower alkyl, R1 stands for lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl or carbohydrazido, R2 stands for hydrogen or lower alkyl with the proviso that if in the formula I R2 stands for hydrogen then R1 cannot stand for nitrile, alkoxycarbonyl or propyl. These compounds are mainly useful as intermediate products for the preparation of valuable pharmaceutically active compounds, but some of the compounds have pharmaceutical activity particularly on the circulatory system. The invention also provides a novel process for preparing the compounds of formulae I and II.

351663

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