3-(sulfonamidoethyl)-indole derivaties for use as...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4155 (2006.01) A61K 31/422 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 29/00 (2006.01) C07D 209/14 (2006.01) C07D 209/16 (2006.01) C07D 209/20 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2496580

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, and Y are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention porte sur des composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, X et Y sont tels que définis dans le descriptif, ou sur un tautomère, un promédicament, un solvate ou un sel de ceux-ci. L'invention porte également sur des compositions pharmaceutiques contenant ces composés et sur des procédés de modulation de la fonction réceptrice des glucocorticoïdes et sur des méthodes de traitement de maladies ou états induits par la fonction réceptrice des glucocorticoïdes ou caractérisés par des processus inflammatoires, allergiques ou prolifératifs chez un patient utilisant ces composés.

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