3-sulfonyl-1,4-dihydropyridines and processes for their...

Details 3-sulfonyl-1,4-dihydropyridines and processes for their... 3-sulfonyl-1,4-dihydropyridines and processes for their...

C - Chemistry, Metallurgy

07

D

260/291.3, 260/2

C07D 211/90 (2006.01) C07D 211/02 (2006.01) C07D 211/84 (2006.01)

Patent

CA 1068706

ABSTRACT OF THE DISCLOSURE The present invention relates to 1,4-dihydropyridines and processes for their preparation of the formula I Image wherein R1 represents phenyl, or phenyl substituted with nitro, tri- fluoromethyl, or dimethylaminosulfamyl; R2 and R3 each independently represent hydrogen, an alkyl group of 1 to 4 carbon atoms or a phenyl group; R4 represents an alkyl group of 1 to 4 carbon atoms or a phenyl group; R5 represents an alkoxy group of 1 to 4 carbon atoms, dimethyl- aminoethoxy, or piperidino; and n is 1 or 2, such as the compounds 2,6-dimethyl-3-carbomethoxy-5-methylsulphonyl-4-(2- trifluoromethylphenyl)-1,4-dihydro-pyridine and to the 2,6-dimethyl-3- carbomethoxy-5-methylsulphonyl-4-)2-nitrophenyl)-1,4-dihydropyridine. They have an antihyperentisive activity.

228197

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