3-thiazol-4-yl-pyprolidine derivatives as amp-specific...

Details 3-thiazol-4-yl-pyprolidine derivatives as amp-specific... 3-thiazol-4-yl-pyprolidine derivatives as amp-specific...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4025 (2006.01) A61K 31/427 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2395114

Novel compounds having formula (I) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

L'invention concerne des nouveaux composés puissants de formule (I) qui sont des inhibiteurs sélectifs de PDE4 ainsi que des procédés de fabrication associés. L'invention concerne également l'utilisation de ces composés pour le traitement de maladies inflammatoires et d'autres maladies faisant intervenir des taux élevés de cytokines ainsi que des maladies du système nerveux central (SNC).

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