3-trifluoromethyl-and 2,5-dimethyl-4'-hydroxy-.alpha.-...

Details 3-trifluoromethyl-and 2,5-dimethyl-4'-hydroxy-.alpha.-... 3-trifluoromethyl-and 2,5-dimethyl-4'-hydroxy-.alpha.-...

C - Chemistry, Metallurgy

07

C

260/618.8

C07C 39/12 (2006.01) C07C 37/055 (2006.01) C07C 37/20 (2006.01) C07C 39/367 (2006.01)

Patent

CA 1211472

Abstract The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- ?-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical character- istics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'- hydroxy-?-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

444189

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