3-unsaturated alkyl cephems from 3-triflyl cephems

Details 3-unsaturated alkyl cephems from 3-triflyl cephems 3-unsaturated alkyl cephems from 3-triflyl cephems

C - Chemistry, Metallurgy

07

D

260/101, 260/101

C07D 501/16 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1340583

There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynyl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(di-benzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.

564370

Affiliated with

Also associated with

Rating

3-unsaturated alkyl cephems from 3-triflyl cephems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-unsaturated alkyl cephems from 3-triflyl cephems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-unsaturated alkyl cephems from 3-triflyl cephems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1190811