3-(ureidocyclohexylamino)-propane-1,2-diol- derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 233/30 (2006.01) C07C 43/23 (2006.01) C07C 275/26 (2006.01) C07C 275/40 (2006.01) C07D 233/32 (2006.01) C07D 233/36 (2006.01) C07D 303/24 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1215711

3-(Ureidocyclohexylamino)-propane-1,2-diol-derivatives Abstract of the disclosure The invention concerns antihypertensive and cardiocative compounds of the formula I (I) Image wherein Ar represents a (monocyclic or optionally partially hydrogen- ated bicyclic) carbocyclic or heterocyclic optionally substituted aromatic radical; R represents hydrogen, alkanoyl or aroyl; R1 and R2 represent independently hydrogen or lower alkyl; or R1 and R2 combined represent alkylene of 2 to 7 carbon atoms separating the two nitrogen atoms thereto attached by 2 to 4 carbon atoms; R3 and R4 independently are hydrogen or lower alkyl; and X represents oxo (O), or thio (S); and salts thereof. They are prepared, for example, by reducing a compound corresponding to the formula I, in which instead of the 1,4-cyclohexylene radical is a 1,4-phenylene radical.

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