C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2651405
The present invention relates to novel 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 36-des(3-methoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyl)rapamycin derivatives in the treatment of cancer and / or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft: vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
La présente invention décrit de nouveaux dérivés de la rapamycine de 36-des(3-méthoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyle), des procédés pour leur production ainsi que leurs utilisations. Sous un autre aspect, la présente invention concerne l'utilisation de ces dérivés de la rapamycine de 36-des(3-méthoxy-4-hydroxycyclohexyl)-36-(3-hydroxycycloheptyle) dans le traitement du cancer et/ou de malignités des lymphocytes B, l'induction ou le maintien de l'immunosuppression, le traitement de rejet de greffe, la réaction de greffe contre l'hôte, les troubles auto-immuns, les maladies inflammatoires, les maladies vasculaires et les maladies fibrogènes, la stimulation de la régénération des neurones ou le traitement de mycoses.
Beckmann Christoph
Sheridan Rose Mary
Wilkinson Barrie
Zhang Ming-Qiang
Biotica Technology Limited
Smart & Biggar
LandOfFree
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