38-decarboxy-38-hydroxymethyl derivatives of teicoplanin...

Details 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin... 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin...

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 38/14 (2006.01) C07K 1/113 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2095725

2095725 9210516 PCTABS00013 The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics and a process for preparing them which comprises submitting the corresponding lower alkyl ester precursor to a reduction reaction in the presence of an alkali metal borohydride. The compounds of the invention show an improved antibacterial activity against some clinical isolates of Staphylococci somewhat resistant to teicoplanin.

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