C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/436 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2651411
The present invention relates to novel 39-desmethoxy-39- methylrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxy- 39-methylrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
La présente invention concerne de nouveaux dérivés de 39-déméthoxy-39-méthylrapamycine, des procédés permettant leur production, et leurs utilisations. Dans un autre aspect, la présente invention concerne l'utilisation de ces dérivés de 39-déméthoxy-39-méthylrapamycine pour le traitement d'un cancer et/ou de malignités des lymphocytes B, l'induction ou le maintien de l'immunosuppression, le traitement d'un rejet de greffe, de la maladie du greffon contre l'hôte, de troubles auto-immuns, de maladies inflammatoires, d'une maladie vasculaire et de maladies fibreuses, de même que son utilisation pour la stimulation de la régénération neuronale ou le traitement d'infections fongiques.
Sheridan Rose Mary
Wilkinson Barrie
Zhang Ming-Qiang
Biotica Technology Limited
Smart & Biggar
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