C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/436 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2600640
The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and / or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
La présente invention concerne des nouveaux dérivés 39-déméthoxyrapamycine, des procédés destinés à leur production et des utilisations desdits dérivés. Sous un autre de ses aspects, la présente invention prévoit l'utilisation de ces dérivés 39-déméthoxyrapamycine dans le traitement de cancers et/ou de tumeurs malignes des cellules bêta, l'induction ou le maintien de l'immunosuppression, le traitement d~un rejet de transplantation, d~une réaction de greffe contre hôte, de maladies auto-immunitaires, de maladies impliquant une inflammation, d~une maladie vasculaire et de maladies fibrogènes, la stimulation de la régénération neuronale ou le traitement de mycoses.
Beckmann Christoph Hendrik
Moss Steven James
Sheridan Rose Mary
Wilkinson Barrie
Zhang Mingqiang
Biotica Technology Limited
Smart & Biggar
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