3d matrix for producing cell transplants

Details 3d matrix for producing cell transplants 3d matrix for producing cell transplants

C - Chemistry, Metallurgy

08

J

C08J 9/28 (2006.01) A61L 27/20 (2006.01) A61L 27/38 (2006.01) C12N 5/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2386586

The invention relates to a method for producing a biologically compatible matrix, to a matrix that can be obtained using the method, and to the use thereof. The invention also relates to an implant. The inventive matrix can be produced by dissolving, in water, chitosan in acid, by freezing the solution and by subsequently lyophilizing the same. Excess acid can be removed by neutralizing with a base before or after the lyophilization. The inventive matrix is dimensionally stable and elastic. When implanted, it induces only a minor immunoreaction.

L'invention concerne un procédé permettant de préparer une matrice présentant une bonne tolérance sur le plan biologique, une matrice obtenue à l'aide dudit procédé, ainsi que son utilisation. L'invention concerne en outre un implant. La matrice est obtenue par dissolution dans l'eau, de chitosane dans de l'acide. La solution est congelée, puis lyophilisée. L'acide excédentaire peut être éliminé par neutralisation avec la base, avant ou après la lyophilisation. Cette matrice est de forme stable et élastique. Lors d'une implantation, elle n'induit que des immunoréactions mineures.

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