C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01)
Patent
CA 2084669
Compounds of formula (I) wherein R is an alkyl group; R1 is a cyano carboxy, alkoxycarbonyl, aminocarbonyl or hy- droxylaminocarbonyl group; R2 is substituted or unsubstituted phenyl, (C3-C7)- cycloalkyl, .alpha.-, .beta.- or .gamma.-pyridyl or a benzohe- terocyclic ring; R3 is carboxy or carboalkoxy; Y is a group of the formula COOX; -NHCOA; -NCO; -COA; -CONHOR e; -OCOA; A; -CO-CH2-CO-R f; -NHCSA; -OCSA; (a); X is hydrogen, alkyl or a succinimidyl group; A is a cyclic of acyclic amino group; and n is 1 or 2; having pharmacological characteristics which render them useful in the treatment of inflam- matory conditions of the respiratory tract and asthmatic conditions.
de Cillis Giampiero
Gallico Licia
Gandolfi Carmelo A.
Long Giorgio
Boehringer Mannheim Italia S.p.a.
F. Hoffmann-La Roche Ag
Kirby Eades Gale Baker
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