(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}...

Details (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}... (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}...

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/495 (2006.01) C07C 69/675 (2006.01) C07C 309/73 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2194397

The novel optically active compound (-)-(3R)-3-methyl-4-{4-[4-(4-pyridyl)- piperazin-1-yl]phenoxy}butyric acid, and pharmaceutically-acceptable salts, esters, amides or solvates thereof. Processes for the preparation of the compound, pharmaceutical compositions containing the compound and its use to inhibit cellular adhesion, for example platelet aggregation.

La présente invention se rapporte à l'acide (-)-(3R)-3-méthyl-4-{4-[4-(4-pyridyl)pipérazin-1-yl]phénoxy}butyrique, nouveau composé doté d'une activité optique, ainsi qu'à ses sels, esters, amides, ou solvates pharmaceutiquement acceptables. Cette invention concerne également des procédés de préparation de ce composé, des compositions pharmaceutiques contenant ce composé et l'utilisation de ce composé comme inhibiteur de l'adhésion cellulaire, et notamment de l'agrégation plaquettaire.

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