C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/80 (2006.01) A61K 31/192 (2006.01) A61K 31/352 (2006.01) A61P 29/00 (2006.01) C07C 62/32 (2006.01)
Patent
CA 2307288
The present invention relates to non-psychoactive derivatives of tetrahydro- cannabinol, which exhibit anti-inflammatory, analgesic and leukocyte antiadhesion activities. The invention includes novel derivatives of (3R,4R)- .DELTA.8-tetrahydrocannabinol-11-oic acids (hereinafter referred to as (3R,4R)- .DELTA.8-THC-11-oic acid), as well as pharmaceutical compositions containing the (3R,4R)-.DELTA.8-THC-11-oic acid derivatives. The invention further covers methods of administering the novel derivatives and pharmaceutical compositions as therapeutic agents in the treatment of pain and tissue inflammation. Non- psychoactive derivatives of .DELTA.8-THC-11-oic acid are described which have analgesic and anti-inflammatory properties.
L'invention concerne des dérivés non psychoactifs de tétrahydro-cannabinol présentant des activités anti-inflammatoire, analgésique et anti-adhésion de leucocytes. L'invention concerne de nouveaux dérivés d'acides (3R, 4R) - .DELTA.?8¿ - tétrahydrocannabinol - 11 - oique [ci-après dénommés acide (3R, 4R) - .DELTA.?8¿ - THC - 11 - oique], ainsi que des compositions pharmaceutiques contenant les dérivés d'acide (3R, 4R) - .DELTA.?8¿ - THC - 11 - oique. L'invention concerne également des méthodes d'administration des nouveaux dérivés et des compositions pharmaceutiques comme agents thérapeutiques dans le traitement de la douleur et d'inflammations de tissus. L'invention concerne aussi des dérivés non psychoactifs d'acide .DELTA.?8¿ - THC - 11 - oiques présentant des propriétés analgésiques et anti-inflammatoires.
Atlantic Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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