(3s,4s)-delta-6-tetrahydrocannabinol-7-oic acids and...

Details (3s,4s)-delta-6-tetrahydrocannabinol-7-oic acids and... (3s,4s)-delta-6-tetrahydrocannabinol-7-oic acids and...

C - Chemistry, Metallurgy

07

D

C07D 311/80 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2118929

The invention relates to novel compounds of formula (I) (see formula I) wherein R is a hydrogen atom or a C1-C5 alkyl group and R2 is selected from the group consisting of: (a) a straight-chained or branched C5- C12 alkyl radical; (b) a group -O-R4, wherein R4 is a straight-chained or branched C2-C9 alkyl radical which may be substituted at the terminal carbon atom by a phenyl group; (c) a group -(CH2)n-O-alkyl, wherein n is an integer of from 1 to 7 and the alkyl group contains from 1 to 5 carbon atoms, having the (3S,4S) configuration, essentially free of the (3R,4R) enantiomer. The invention also relates to process for the preparation of compounds of formula (I) as defined above. The invention further relates to pharmaceutical compositions which possess analgesic, anti-inflammatory, anti-emetic, anti- glaucoma, leukocytes antiadhesion or PAF activity, containing as active ingredient compounds of formula (I) as defined above.

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