C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/107 (2006.01) A61K 31/404 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2481036
The present invention relates to organic molecules represented by the general formula (I) wherein: X is O; Y is [C(R2)2]c;. R, R1, R2,-a, b and c are as disclosed in the description; and pharmaceutically acceptable salts thereof, capable of modulating tyrosine kings signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
L'invention concerne des molécules organiques de formule générale I, dans laquelle X représente O; Y représente [C(R?2¿)¿2?]¿c?; R, R?1¿, R?2¿, a, b et c sont tels que définis dans la description, ainsi que des sels pharmaceutiquement acceptables de celles-ci. Les molécules selon l'invention peuvent moduler la transduction des signaux de tyrosine kinases, de sorte à réguler, moduler et/ou inhiber la prolifération cellulaire anormale.
Andrews Steven W.
Guo Xialing
Hull Clarence E. III
Malone Thomas
Wang Edward H.
Allergan Inc.
Gowling Lafleur Henderson Llp
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