4-(1-isoquinolyl)-piperidin-4-ol compounds and their...

Details 4-(1-isoquinolyl)-piperidin-4-ol compounds and their... 4-(1-isoquinolyl)-piperidin-4-ol compounds and their...

C - Chemistry, Metallurgy

07

D

260/277.3

C07D 401/04 (2006.01) A61K 31/47 (2006.01) C07D 211/04 (2006.01) C07D 217/04 (2006.01) C07D 211/06 (2006.01)

Patent

CA 1073910

ABSTRACT OF THE DISCLOSURE Isoquinolines of the formula Image wherein R1 is H or alkyl of 1 - 4 carbon atoms, R2 is H and R3 is OH, or R2 and R3 collectively are a C-C bond, and physio- logically acceptable acid addition salts thereof have anti depressant activity. These isoquinolines can be prepared by solvolyzing or hydrogenolyzing a compound of the formula Image or an acid addition salt thereof, wherein R4 is R1 or R6, R5 is OR7 or, when R4 is R6, is R3; R6 and R7 are radicals which can be split off solvolytically or hydrogenolytically and R1 and R2 are as above. A resulting carbinol (R2 is H, R3 is OH) may be dehydrated; and/or a resulting compound (R1 is H) may be treated with a N-alkylating agent; and/or a resulting base may be converted to a physiologically acceptable acid addition salt by treatment with an acid.

280267

Affiliated with

Also associated with

Rating

4-(1-isoquinolyl)-piperidin-4-ol compounds and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-(1-isoquinolyl)-piperidin-4-ol compounds and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-(1-isoquinolyl)-piperidin-4-ol compounds and their... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-951663