4-[2-(2-substituted phenyl)ethenyl]-n-alkenyl or alkinyl...

Details 4-[2-(2-substituted phenyl)ethenyl]-n-alkenyl or alkinyl... 4-[2-(2-substituted phenyl)ethenyl]-n-alkenyl or alkinyl...

C - Chemistry, Metallurgy

07

D

260/294

C07D 211/70 (2006.01)

Patent

CA 1116171

HA158 Abstract 4-[2-(2-SUBSTITUTED PHENYL)ETHENYL]-N-ALKENYL OR ALKINYL SUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINES Compounds of the formula and their pharmaceutically acceptable acid addition salts Image wherein X is lower alkoxy, C1, Br, or F; R is Image or C=C-R4; R1, R2, R3, and R4 are independently selected from hydrogen and methyl; n is an integer from 1 to 3 provided that when n is 3 at least two of R1, R2 and R3 are hydrogen and R4 is hydrogen, and further provided that when n is 2 at least one of R1, R2 and R3 is hydrogen; are disclosed. These compounds possess useful pharmaceutical activities due to their ability to inhibit the prostaglandin-inactivating enzyme 15-.alpha.- hydroxyprostaglandin dehydrogenase.

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