4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 211/20 (2006.01) A61K 31/451 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2708785

The compound 4-[2,3-Difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]- piperidine according to the structure (formula I), and pharmaceutically acceptable salts thereof are provided for the treatment of CNS related disorders, such as : depres-sive disorder, dysthymic disorder; mood disorder due to a general medical condition; atypical depression; seasonal affective disor-der; melancholia; treatment resistant depression; partial responders; depression associated with bipolar disorder, pain, Alzheimer's disease, psychosis, Parkinson's disease, Lewy body disease, Huntington's disease, multiple sclerosis or anxiety; general anxiety dis-order, social anxiety disorder, panic attacks; phobia; social phobia, obsessive compulsive disorder; post traumatic stress disorder, acute stress; ADHD; and pain.

L'invention porte sur le composé 4-[2,3-difluoro-6-(2-fluoro-4-méthylphénylsulfanyl)phényl]pipéridine et ses sels pharmaceutiquement acceptables pour le traitement de troubles liés au système nerveux central, tels que : un trouble dépressif, un trouble dysthymique; un trouble de l'humeur dû à un état médical général; une dépression atypique; une dépression saisonnière; la mélancolie; une dépression résistante aux traitements; des répondeurs partiels; une dépression associée à un trouble bipolaire, la douleur, la maladie d'Alzheimer, une psychose, la maladie de Parkinson, une maladie à corps de Lewy, la maladie d'Huntington, la sclérose en plaque ou l'anxiété; un trouble d'anxiété générale, un trouble d'anxiété sociale, des crises de panique; une phobie; une phobie sociale, un trouble obsessionnel-compulsif; un état de stress post-traumatique, un stress aigu; un trouble d'hyperactivité avec déficit de l'attention; et la douleur.

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