C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/44 (2006.01) A61K 31/4706 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2581807
This invention relates to compounds of the formula (I): wherein: R is methyl or ethyl; R' and R" are independently alkyl of 1 to 3 carbon atoms, or R' and R", taken together with the nitrogen to which they are attached, can form a 5 or 6 membered saturated ring which may optionally contain an additional heteroatom selected from NR"', O or S(O)n; n is 0-2; and R"' is hydrogen or alkyl of 1 to 3 carbon atoms; and pharmaceutically acceptable salts thereof, and their use for inhibiting vascular permeability caused by disease, injury or other trauma.
L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ces composés, ainsi que leur utilisation pour inhiber une perméabilité vasculaire provoquée par une maladie, une lésion ou un autre traumatisme. Dans cette formule, R désigne méthyle ou éthyle; R' et R" désignent indépendamment un alkyle C1-3, ou R' et R", pris ensemble avec de l'azote auquel ils sont fixés, peuvent former un anneau saturé à 5 ou 6 éléments pouvant éventuellement contenir un hétéroatome supplémentaire sélectionné dans: NR"', O ou S(O)n; n étant compris entre 0 et 2; et R"' désigne hydrogène ou alkyle C1-3.
Barrios-Sosa Ana Carolina
Boschelli Diane Harris
Zaleska Margaret
Smart & Biggar
Wyeth
LandOfFree
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