4- (2,6-dichloro-benzoylamino) -1h-pyrazole-3-carboxylic...

Details 4- (2,6-dichloro-benzoylamino) -1h-pyrazole-3-carboxylic... 4- (2,6-dichloro-benzoylamino) -1h-pyrazole-3-carboxylic...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4155 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2651152

The invention provides the compound of formula (I) 4-(2,6-dichloro-benzoylamino)-1H-pyrazole- 3-carboxylic acid (l-methanesulphonyl-piperidin-4-yl)-amide in a substantially crystalline form, therapeutic uses thereof and pharmaceutical compositions containing the crystalline compound. The invention also provides novel pharmaceutical formulations containing 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)-amide and novel processes for preparing the compound.

La présente invention concerne le composé formule (I) (1-méthanesulfonyl-pipéridin-4-yl)-amide de l'acide 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylique sous forme sensiblement cristalline, ses applications thérapeutiques et les compositions pharmaceutiques contenant le composé cristallin. La présente invention concerne également de nouvelles formules pharmaceutiques contenant le (1-méthanesulfonyl-pipéridin-4-yl)-amide de l'acide 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylique et de nouveaux procédés de synthèse du composé.

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