4- (2, 6-dichlorobenzoylamino) -lh-pyrazole-3 -carboxylic...

Details 4- (2, 6-dichlorobenzoylamino) -lh-pyrazole-3 -carboxylic... 4- (2, 6-dichlorobenzoylamino) -lh-pyrazole-3 -carboxylic...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2593560

The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)- lH- pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6- dichloro-benzoylamino)-lH- pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4- (2,6-dichloro-benzoylamino)-lH-pyrazole-3- carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

L'invention concerne un sel d'ajout d'acide de pipéridine-4-ylamide acide de 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylique et des cristaux de celui-ci. Ce sel est constitué d'un acide sélectionné dans le groupe comprenant de l'acide méthanesulfonique et de l'acide acétique, ainsi que des mélanges de ceux-ci. L'invention concerne également de nouvelles utilisations de sels de pipéridine-4-ylamide d'acide 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylique. L'invention concerne encore des procédés pour la préparation de pipéridine-4-ylamide 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylique et de ses sels, ainsi que de nouveaux intermédiaires chimiques.

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