C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2563042
The present invention is to provide a novel heterocyclic compound of the formula [I]: wherein R1 is a halogen, nitro, an alkyl, etc.; R2 is hydrogen, an alkyl, etc.; Ring A is 2-oxo-4-imidazolin-3,4-diyl, etc.; Ring B is a cycloalkyl, monocyclic saturated heterocyclic group; X is CH, N; Y is a single bond, CO, SO2; Z is O, NH, etc.; and Ring C is an aryl, a heterocyclic group, or a pharmaceutically acceptable salt thereof, which is useful as a p38 MAP kinase inhibitor.
La présente invention consiste à fournir un nouveau composé hétérocyclique de formule [I] : dans laquelle R¿1? est un halogène, un nitro, un alkyle, etc. ; R¿2? est un hydrogène, un alkyle, etc. ; le cycle A est un 2-oxo-4-imidazolin-3,4-diyle, etc. ; le cycle B est un cycloalkyle, un groupe hétérocyclique monocyclique saturé ; X est CH, N ; Y est une liaison simple, CO, SO2 ; Z est O, NH, etc. ; et le cycle C est un aryle, un groupe hétérocyclique, ou un sel acceptable du point de vue pharmaceutique de celui-ci, lequel est utile comme inhibiteur de MAP-kinase p38.
Kubo Akira
Miyoshi Hidetaka
Murakami Takanori
Nakajima Tatsuo
Nakane Tetsu
Marks & Clerk
Mitsubishi Tanabe Pharma Corporation
Tanabe Seiyaku Co. Ltd.
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